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The SEISMIC study is a Phase III, multi-center study of Corlux for the treatment of endogenous Cushing's Syndrome.
It is a 6-month study with daily dosing of the investigational drug, Corlux. It is open label, that is, no placebo is required. The protocol includes about 13 clinic visits. After the 6 month treatment period is over, patients return for a 6-week follow up visit.
The study will enroll 50 Cushing's Syndrome patients at approximately 20-25 sites in the US.
The SEISMIC study is seeking patients who require medical treatment for endogenous Cushing's Syndrome due to ectopic ACTH syndrome, adrenal tumors, adrenal hyperplasia, or Cushing's disease when they are not candidates for pituitary surgery or who have failed or recurred after pituitary surgery. Please see detailed eligibility criteria.
See if you are a candidate for this breakthrough Cushing's Syndrome clinical trial
Cushings Articles
Cushing's Syndrome Clinical Trial Qualification Questionnaire
On Dec 05, 2008, Adrian wrote:
The SEISMIC study is seeking patients who require medical treatment for endogenous Cushing's Syndrome due to ectopic ACTH syndrome, adrenal tumors, adrenal hyperplasia, or Cushing's disease when they are not candidates for pituitary surgery or who have failed or recurred after pituitary surgery.
Medical Professionals Interested in Cushing's Syndrome
On Jul 14, 2008, ClinicalTrialWatch Editor wrote:
Medical Professionals: Learn More About The Cushing's Syndrome Clinical Study Study Purpose The SEISMIC Study is a Phase III open label US based clinical research trial designed to test mifepristone in the treatment of the clinical manifestations of endogenous Cushing's ...
SEISMIC Study Eligibility Criteria
On Jul 08, 2008, ClinicalTrialWatch Editor wrote:
SEISMIC Study Main Inclusion Criteria Patients please take the questionnaire Cushing's Syndrome Clinical Trial Qualification Questionnaire to see if you prequalify for the study. Physicians and health care providers view the inclusion and exclusion criteria below and read our ...
Additional Publications and Research
On Jul 07, 2008, ClinicalTrialWatch Editor wrote:
External Publications about Cushing's Syndrome Sartor O, Cutler GB Jr. Mifepristone: treatment of Cushing's syndrome. Clin Obstet Gynecol. 1996 Jun;39(2):50610. Review. http://www.ncbi.nlm.nih.gov/pubmed/8734015?dopt=Abstract Johanssen S, Allolio ...
Friends and Family of Cushing's Syndrome Patients
On Jul 07, 2008, ClinicalTrialWatch Editor wrote:
you know someone suffering with Cushing's Syndrome and believe they may be a candidate for this Phase III clinical trial, please tell them about the SEISMIC Study by sending them a link to the Cushing's Syndrome Clinical Trial Qualification Questionnaire. Please also ...
On Jul 07, 2008, ClinicalTrialWatch Editor wrote:
What is Cushing's Syndrome? Cushing's syndrome was originally described by Harvey Cushing in 1932 and is a relatively rare but serious condition. It is caused by a prolonged exposure to elevated levels of the stress hormone cortisol. Cortisol is produced and released by the adrenal glands; it is necessary for many bodily ...