The Penn Pituitary Center at Penn Medicine is a multidisciplinary group of physicians who are recognized internationally for their expertise in the diagnosis and treatment of neuroendocrine diseases, including acromegaly, Cushing’s disease, hyperprolactinemia, gonadotroph and other clinically nonfunctioning pituitary adenomas, and other pituitary and hypothalalmic lesions, as well as hypopituitarism and diabetes insipidus.

The Penn Pituitary Center features physicians from many specialties who combine the greatest experience in treating patients with pituitary disease with the latest technologies of diagnosis and treatment.

Penn Pituitary Center physicians are already experienced in the latest medications and techniques because they were instrumental in their development.


A multidisciplinary team of endocrinologists, neurosurgeons, radiation oncologists, neuroradiologists, interventional radiologists, and neuroophthalmologists work together to provide the latest specialized care needed by a patient with a pituitary or hypothalamic tumor or with pituitary hormone excess or deficiency.

These specialists meet every month as a group at the Sellar Conference to discuss the management of patients with neuroendocrine disease.


Diagnostic Resources

    • Provocative endocrine testing.  These include stimulation and suppression of growth hormone, CRH testing, metyrapone testing, and water deprivation testing.


    • Inferior petrosal sinus sampling.  This technique, performed in Interventional Radiology, distinguishes Cushing’s disease from ectopic ACTH syndrome.


    • High resolution MRI (3T). High resolution improves visualization of the pituitary and surrounding structures.


Therapeutic Resources

    • Patient instruction. A dedicated Penn Pituitary Center nurse instructs patients in self-administration of specialized neuroendocrine medications.


    • Clinical trials. The Center often participates in clinical trials of new neuroendocrine medications, which offers our patients access to new medications not otherwise available.


    • Neurosurgery. Penn Pituitary Center neurosurgeons use advanced endoscopic and microscopic techniques along with intraoperative image guidance to get the best therapeutic results.


    • Intensity Modulated Radiation Therapy (IMRT). Five to seven modulated fields of radiation are used to precisely shape the radiation field to conform to the target and avoid normal tissue. The Z Med localization devise allows for millimeter accuracy of daily positioning and monitors positioning during the treatment.


    • “Gamma Knife” Radiation.  A single high dose of gamma radiation is delivered stereotactically to the tumor.


  • Proton Beam Therapy. Use of protons to treat tumors offers the advantage of delivering a high dose to the tumor but a very small dose to the surrounding normal tissue. 


Peter J. Snyder, MD

Julia Kharlip, MD


M. Sean Grady, MD

John Y. K. Lee, MD

Radiation Oncology

Robert Lustig, MD

Michelle Alonso-Basanta, MD, PhD

Interventional Radiology

Robert W. Hurst, MD

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